Icariin

Product Name: Icariin
CAS: 489-32-7
EINECS: 610-440-0
Molecular Formula: C33H40O15
Molecular Weight: 676.66
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Certificate: ISO9001, ISO22000, HALAL, KOSHER, FDA

What Is Icariin?
Icariin, also known as icariin, is the main active ingredient of Epimedium. Icariin is a light yellow needle-shaped crystalline powder, soluble in ethanol and ethyl acetate, and difficult to dissolve in water. It is the main active ingredient of total flavonoids extracted from the stems and leaves of Epimedium, a plant of the Berberidaceae family.

Epimedium is warm in nature, pungent and sweet in taste, and enters the liver and kidney meridians. It has the effects of tonifying the kidney and yang, dispelling wind and dampness, and strengthening tendons and bones. Icariin is the main active ingredient of the stems and leaves of Epimedium. Modern pharmacological studies have found that it has strong biological activity on bone tissue, immune system, tumor tissue and nervous system. Icariin has immunomodulatory, anti-inflammatory, anti-aging, anti-tumor and other activities, and has a certain improvement effect on related diseases such as nerves, immunity, endocrine, cardiovascular, and bones.

Product Details Form

Molecular Structure

Physical and chemical properties
Icariin is a light yellow needle-shaped crystalline powder
Soluble in ethanol and ethyl acetate, poorly soluble in water, insoluble in ether, benzene, and chloroform
It reacts with ferric chloride to produce green color, and reacts with magnesium hydrochloride powder to produce orange-red color.

Source Of The Extract
Dried stem and leaf extracts of Epimedium brevicornum Maxim., Epimedium sagittatum Maxim., Epimedium pubescens Maxim., Epimedium wushanense T.S.Ying, or Epimedium koreanum Nakai, all of the Berberidaceae family.

Function
1. Anti-inflammatory and antioxidant effects
Icariin also has certain anti-inflammatory and antioxidant effects, can inhibit inflammatory reactions and the production of free radicals, and has a therapeutic effect on a variety of inflammatory diseases and oxidative stress-related diseases. This helps to reduce tissue damage caused by inflammation and promote the repair and regeneration of damaged tissues.
2. Anti-aging
Icariin affects cell proliferation, prolongs the growth period, regulates the immune and secretory systems, and improves the body's metabolism and organ functions.
3. Enhance the function of the immune system
Icariin has an immunomodulatory effect, which can enhance the body's immune function, increase the number and activity of white blood cells, and enhance the body's resistance to viruses and bacteria. Therefore, icariin has a certain role in enhancing human immunity.
4. Improve cardiovascular function
Icariin can block angiotensin II-induced cardiomyocyte hypertrophy and apoptosis by inhibiting the activation of JNK and p38 pathways; activate ERK, remove reactive oxygen species, and inhibit oxidative stress in cardiomyocytes.
Icariin can dilate coronary arteries, increase myocardial blood flow, lower blood pressure and blood lipid levels, and thus improve cardiovascular function. Icariin can protect the cardiovascular system by protecting myocardial cells, promoting myocardial cell generation, and improving endothelial dysfunction. This is beneficial for the prevention and treatment of cardiovascular diseases such as coronary heart disease and hypertension.
5. Protect the nervous system
Icariin can increase the level of superoxide dismutase (SOD), reduce the expression of amyloid precursor protein and β-secretase, reduce the production and accumulation of Aβ, weaken the atrophy of axons and dendrites mediated by Aβ, and improve the spatial learning and memory ability of Alzheimer's disease model rats. Icariin can also inhibit the hyperphosphorylation of tau protein serine 396, 404 and threonine 205 sites induced by Aβ, thereby protecting nerve cells.
Improve symptoms such as cerebral ischemia and brain damage, and promote the repair and regeneration of neurons, which has certain potential for the prevention and treatment of neurological diseases such as Alzheimer's disease and Parkinson's disease.
6. Promote bone metabolism and prevent osteoporosis
Icariin can promote the formation and activation of osteoblasts, while inhibiting the formation and function of osteoclasts to alleviate osteoporosis and maintain the health of bones. Icariin can activate the mitogen-activated protein kinase (MAPK) signaling pathway, increase the gene expression of type I collagen, osteocalcin and osteocin, enhance the self-renewal ability of bone mesenchymal stem cells (BMSCs) in vivo and in vitro, induce BMSCs to differentiate into osteoblasts, and then enhance osteogenic differentiation.
Icariin can reduce the generation of superoxide anions and the size and number of actin rings, reduce intracellular calcium concentration, inhibit osteoclast activity, and thus inhibit bone resorption.

Application
Food
The food industry has used icariin as a functional factor and has been widely used in soft capsules, capsules, and strong wine.
Icariin extract is a solid beverage product made by extracting, concentrating, and spray drying icariin. It is mainly used in food, solid beverages, beverages, and other fields. It has certain nutritional value and the unique smell and taste of icariin.
Health products
Icariin is widely used in health products because it can enhance immune function, maintain bone health and cardiovascular system, and protect the nervous system.
Cosmetics
Icariin has the effects of repairing skin barrier, anti-wrinkle and antioxidant, moisturizing, and soothing and anti-inflammatory. These functions make it an ideal ingredient in cosmetic research and development. Icariin can effectively improve skin condition and provide all-round care for the skin.