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98% Nobiletin Powder CAS 478-01-3

CAS No.: 478-01-3

Molecular Formula: C₂₁H₂₂O₄

Molecular Weight: 402.39

EINECS No.: 251-228-4

Test Method: HPLC

Melting Point: 137-138°C

Specification: 40%-98%

Solubility: Soluble in DMSO (up to 10 mg/ml)

    What is Nobiletin?

    Nobiletin is a natural polymethoxylated flavonoid compound primarily found in citrus peels and is one of their main active ingredients. It exhibits diverse biological activities, including antioxidant, anti-inflammatory, antimicrobial, and neuroprotective activities.

     

    Animal studies at the University of Ottawa Heart Institute in Canada have shown that nobiletin can improve metabolic disorders induced by a high-fat diet and effectively prevent postprandial hyperlipidemia. Epidemiological data further support the correlation between flavonoid intake and reduced cardiovascular risk, suggesting the potential application of nobiletin in metabolic health.

     

    In addition, multiple studies have found that this ingredient exhibits promising potential in preventing neurodegenerative diseases and inhibiting allergic reactions, providing scientific support for its application in functional foods and pharmaceuticals.

    What are the benefits?

    Nobiletin promotes adipocyte secretion of adiponectin, a hormone that plays a crucial role in improving insulin sensitivity and regulating insulin secretion, offering positive benefits for diabetes prevention. It also promotes adipocyte differentiation and accelerates intracellular lipolysis, helping to improve lipid metabolism.

     

    In terms of metabolic regulation, nobiletin exhibits dual effects by inhibiting both elevated blood sugar and blood pressure, and is considered potentially valuable for preventing metabolic syndrome. Its mechanism of action is closely related to regulating multiple metabolic pathways.

     

    Regarding allergic reactions, nobiletin modulates immune balance by inhibiting the release of inflammatory mediators such as histamine, thereby exerting anti-allergic effects.

     

    Regarding inflammation regulation, this ingredient activates the expression of proteins associated with the suppression of chronic inflammation, effectively alleviating inflammatory responses and associated pain symptoms. This mechanism is crucial for preventing lifestyle diseases such as metabolic syndrome and arteriosclerosis, which are caused by chronic inflammation.

    Application direction

    Nutritional Enhancer
    Nobiletin can be added to foods as a functional ingredient, effectively enhancing the nutritional value and health benefits of the product.

    Skin Care
    Thanks to its vitamin P-like properties, nobiletin is used in skin care formulations to help prevent frostbite. Its combined anti-inflammatory and antiviral properties also make it a useful ingredient in oral care products, helping to inhibit plaque formation and improve oral odor.

    Oral Care
    In oral hygiene products, nobiletin works through a dual mechanism of action: inhibiting plaque accumulation while helping to reduce bad breath and improve oral health.

    Sunscreen
    This ingredient has UV absorption and blocking properties, making it a natural UV protectant in sunscreens and other photoprotective preparations.

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