Wholesale Pure 98% Glycyrrhetnic acid Powder

Glycyrrhetinic acid is a hydrolysis product of glycyrrhizin, the main active component of licorice, and belongs to the pentacyclic triterpenoid class of compounds. In the body, glycyrrhizin breaks down into glycyrrhetinic acid and two molecules of glucuronic acid. Its salts (such as ammonium glycyrrhizinate and dipotassium glycyrrhizinate) also hydrolyze to form glycyrrhetinic acid.

● Appearance: White to light yellow powder

● Solubility: Poorly soluble in water, easily soluble in ethanol and ether

● Bioactivity: Glycyrrhetinic acid exhibits stronger biological activity compared to glycyrrhizin and its salts.

● Structurally similar to hydrocortisone, exhibiting potent anti-inflammatory activity by inhibiting inflammatory mediators such as prostaglandin PGE2 and histamine.

● Reduces inflammation by blocking phospholipase A2 and lipoxygenase, thereby inhibiting the arachidonic acid metabolism pathway.

2. Antibacterial & Repairing Effects

● Reduces capillary permeability, lowering the risk of bacterial infections.

● Suitable for lip balms (to prevent dryness and cracking) and oral care products (to prevent cavities and mouth ulcers).

3. Whitening Support

● Inhibits inflammation-induced pigmentation, reducing dark spots, improving skin texture, and brightening skin tone.

4. Hormone-Like Effects (Without Side Effects)

● Exhibits glucocorticoid-like activity by enhancing hormone receptor function, but without the adverse effects associated with steroid medications.

● Widely used in lipid-soluble skincare products, offering anti-inflammatory, whitening, and skin-repairing benefits.