Wholesale 98% Cycloastragenol Powder

Cycloastragenol, a tetracyclic triterpenoid saponin with significant biological activity, has garnered widespread attention in the scientific community due to its unique chemical structure and pharmacological properties. This natural compound is primarily derived from the traditional Chinese medicinal herb Astragalus and can be obtained through the hydrolysis of Astragaloside IV. Its molecular structure contains multiple active functional groups, which are closely related to its distinctive biological activities.

In terms of molecular mechanisms, cycloastragenol exhibits an unprecedented ability to activate telomerase, making it the only known natural small molecule capable of directly activating this enzyme. Its mechanism of action operates on multiple levels:

● At the gene expression level, it significantly upregulates the expression of telomerase reverse transcriptase (TERT).

● At the enzymatic activity level, it enhances the catalytic function of telomerase.

● At the cellular protection level, it helps maintain telomere length, thereby slowing down cellular aging.

This multi-target mode of action grants cycloastragenol a unique advantage in the field of anti-aging research.

● Telomere Extension: By activating telomerase (TERT), CAG slows down telomere shortening, maintains cellular replication capacity, and extends cell lifespan.

● Tissue Regeneration: Supports increased cell division, enhances the body's ability to replace aging and damaged cells, and may slow overall aging.

● Clinical Research:

◆ CAG has been confirmed to activate human telomerase, demonstrating anti-aging potential.

◆ Reduces fine lines and wrinkles, improving skin condition.

◆ Enhances immunity, improves vision, and other health indicators.

◆ Limitations: Currently, there is no direct evidence proving that CAG can extend human lifespan.

● Reduces imiquimod-induced skin thickening.

● Dose-dependently decreases inflammatory factors such as TNF-α and IL-6.

● Increases melanin production by activating the p38 signaling pathway, potentially useful for vitiligo treatment.

● Cardiovascular Protection: Lowers blood lipids, improves vascular function, and delays arteriosclerosis.

● Neuroprotection:

Reduces ischemia-reperfusion injury in the brain and increases TERT expression in brain tissue.

Inhibits neuronal apoptosis, potentially benefiting stroke and Alzheimer’s disease treatment.

● Bone Health: Slows down osteoporosis progression.

● Antiviral: May have inhibitory effects on certain viruses.

● Lung Protection: Reduces lung damage and improves respiratory function.

● Antidepressant: Potential regulation of neurotransmitter activity.

As a telomerase activator, cycloastragenol (CAG) shows broad potential in anti-aging, skin repair, neuroprotection, and metabolic disease intervention. Although its anti-aging effects have shown promise in preclinical studies, further long-term human trials are needed to validate its safety and efficacy.