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Bisabolol: Product Introduction
Bisabolol is a sesquiterpene alcohol compound widely found in plants such as chamomile and myrrh. It possesses excellent anti-inflammatory, soothing, and repairing effects, and is widely used in cosmetics, personal care, and pharmaceuticals, especially suitable for sensitive skin. YTBIO provides high-quality natural and synthetic bisabolol to meet different application scenarios and cost requirements.
Product Efficacy and Features
Anti-inflammatory and Soothing Effects
Bisabolol fundamentally reduces the production of key inflammatory mediators such as leukotrienes and prostaglandins by inhibiting the activity of 5-lipoxygenase (5-LOX) and cyclooxygenase (COX), effectively relieving skin erythema, edema, and stinging caused by chemical irritation and UV radiation.
Powerful Antioxidant
As a natural antioxidant, bisabolol can scavenge excess free radicals caused by UV radiation and environmental pollution, enhance the activity of antioxidant enzymes such as superoxide dismutase (SOD), reduce lipid peroxidation, protect the skin from oxidative stress damage, and slow down skin aging.
Repairing the Skin Barrier
Bisabolol can activate keratinocyte proliferation and promote the repair of damaged skin barriers. It also helps enhance the function of the sebum film, maintain the skin's water-oil balance, and accelerate wound healing.
Studies have found that α-bisabolol can promote wound healing (effective medium concentration ED50 is 155 µg/mL), and in mouse experiments, it was effective when used immediately after wound suturing. This effect may be related to its specific chemical structure. Although it has little effect on fibroblast migration, it still accelerates the healing process. The figure below illustrates its role in skin diseases and wound healing.
Broad-spectrum antibacterial activity
Bisabolol has inhibitory effects on common skin pathogens such as Staphylococcus aureus and Propionibacterium acnes.
The antimicrobial actions of α-Bisabolol against different bacterial strains：
|
Compound |
Dose/Route/ |
Model |
Major Mechanisms |
|
α-Bisabolol |
4–512 μg/mL (for bacteria) |
Staphylococcus aureus, Candida albicans, Candida krusei, Candida tropicalis |
Inhibited microbial growth |
|
α-Bisabolol |
1024 μg/mL |
Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa |
Inhibited microbial growth |
|
α-Bisabolol |
1024 µg/mL |
Staphylococcus aureus strains: pT181 carrying the TetK efflux pump protein that extrudes tetracycline; and the 1199B that presents resistance to norfloxacin by NorA pump expression |
↓ MIC for tetracycline and norfloxacin |
|
α-Bisabolol |
0.1% |
Bacillus Solobacterium moorei |
↓ colonies number |
|
α-Bisabolol |
0.5–2 mM |
Staphylococcus aureus and Escherichia coli |
↑ effect of co-administered antibiotics |
|
α-Bisabolol |
0.281–9 mM for 3 days |
Aspergillus fumigatus Af239 |
↓ fungal growth |
|
α-Bisabolol |
5, 10, 20, 50, 100, 200 μg/mL |
Microsporum gypseum, Microsporum canis, Trichophyton violaceum, Nannizzia cajetani, Trichophyton mentagrophytes, Epidermophyton floccosum, Arthroderma gypseum, Trichophyton rubrum and Trichophyton tonsurans |
↓ fungal growth |
|
α-Bisabolol |
1 µg/mL |
Fusarium oxysporum |
↓ fungal growth |
|
α-Bisabolol |
1000–31.25 μM |
Trypanosoma cruzi Y infected LLC-MK2 cells |
↓ cell viability |
|
α-Bisabolol |
1000–6.25 μg/mL |
Leishmania infantum zymodeme 1 |
↓ parasite growth |
|
α-Bisabolol |
IC50 = 9.5, 16.0 |
Promastigotes of Leishmania infantum and amazonensis |
↓ parasite growth |
|
α-Bisabolol |
1.86–60 μg/mL |
MHOM/BR/76/Ma-76 Leishmania amazonensis strains |
(-) parasite growth |
|
α-Bisabolol |
50, 200, and 1000 mg/kg p.o for 14 days |
107 stationary-phase promastigotes of Leishmania infantum injected in mice |
(-) parasite growth |
|
α-Bisabolol |
25 and 100 μM |
Leishmania tropica promastigotes |
(-) parasite growth |
|
α-Bisabolol |
30 mg/kg, p.o, once daily for 28 days |
Canine leishmaniosis naturally infected dogs |
↓ parasite load |
|
α-Bisabolol |
1%, 2.5%, 5% applied ointment, 200 mg/kg p.o. for 21 days |
Inoculated 3 × 107 parasites in the left hind footpad of hamsters |
↓ lesion thickness |
Symbols indications: ↑; increase, ↓; decrease, (-); reduce.
Stable Performance
Bisabolol possesses a lipid-soluble molecular structure, allowing it to effectively penetrate the stratum corneum of the skin to exert its effects. It also exhibits good stability in formulations, resisting oxidation and decomposition.
References:Eddin LB, Jha NK, Goyal SN, Agrawal YO, Subramanya SB, Bastaki SMA, Ojha S. Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol. Nutrients. 2022 Mar 25;14(7):1370. doi: 10.3390/nu14071370. PMID: 35405982; PMCID: PMC9002489.
Application Areas Overview
1. Cosmetics and Personal Care
Skincare Products: Bisabolol is often added to soothing and repairing skincare products, helping to improve redness, stinging, and allergies.
Sunscreen/After-Sun Products: Bisabolol is also commonly used in after-sun gels and sprays to reduce inflammation and burning discomfort caused by UV rays.
Baby Care: Used in baby creams and diaper rash creams to soothe irritation.
Oral Care: Often added to toothpaste and mouthwash to inhibit gum bacteria and reduce gum bleeding and bad breath.
Cleansing Products: Also works directly in facial cleansers and shampoos.
2. Pharmaceuticals
Used for inflammatory skin diseases such as eczema and contact dermatitis.
Recommended concentration
|
Product Category |
Recommended Usage Concentration |
|
Shampoo |
0.1 - 1% |
|
Primer / Makeup Base Cream |
0.2 - 1% |
|
Facial & Neck Products |
0.1 - 1% |
|
Body & Hand Products |
0.1 - 0.5% |
|
Mask Products (e.g., Face Mask) |
0.1 - 0.5% |
Recommended concentrations and application suggestions are based on existing reference materials and industry experience. Please conduct tests according to your own circumstances to ensure the safety and compliance of the product.
Why Choose YTBIO?
Own Factory, Direct Supply: We own our production base, ensuring a stable supply chain.
12+ Years of Industry Experience: Providing you with professional technical support and solutions.
System Certifications: Our production and quality management systems have passed multiple international authoritative certifications, including: cGMP, FSSC22000, BRC, HACCP, HALAL, KOSHER, ISO9001, ISO22000, etc.
Quality Assurance: All products undergo rigorous quality inspection to ensure high purity and low impurities.
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