0102030405
Natural Pepper Extract Piperine Powder
What is piperine?
Piperine is an alkaloid with significant anticonvulsant activity, with the chemical formula C17H19NO3. It is primarily extracted from the dried fruits of black pepper (Piper nigrum L.). This substance appears as a colorless monoclinic prismatic crystal, is odorless, and has a burning sensation when tasted. Its aqueous solution reacts neutrally with litmus paper.
In terms of solubility, piperine shows notable selectivity: it is highly soluble in organic solvents such as chloroform, ethanol, and ether. It also dissolves well in benzene and acetic acid but is almost insoluble in water and petroleum ether.
Pharmacological studies indicate that piperine has broad-spectrum anticonvulsant properties. In addition to its central nervous system effects, piperine also exhibits strong insecticidal activity, with toxicity to flies even surpassing that of natural pyrethrins. These diverse biological activities make piperine a natural compound with significant medicinal value.
What are the benefits?
Antioxidant Effect
DPPH free radical scavenging experiments confirm that
● The antioxidant capacity is 60.05% that of vitamin C
● It exhibits good stability in acidic environments
Central Nervous System Effects
Sedative and Hypnotic Effects:
● Reduces spontaneous activity in mice
● Prolongs pentobarbital sodium-induced sleep time
● Increases deep sleep in rabbits
Mechanism of Action:
● Increases serotonin levels in the brain
Also has anticonvulsant and antidepressant effects
Immune Modulatory Function
● No significant toxicity after continuous administration for 5 days
● Normal liver weight increase
Regulation of Thymus Cell Function:
● Inhibits reactive oxygen species (ROS) generation
● Increases glutathione levels
● Reduces cell apoptosis
● Modulates lymphocyte phenotype
Anti-inflammatory and Comprehensive Pharmacological Effects
● Significant anti-inflammatory effects (50 mg/kg oral dose)
Transdermal Absorption Characteristics:
● Acts on subcutaneous tissue
● Affects neurovascular function
Other Effects:
● Prevents atherosclerosis
● Regulates blood lipids
● Ant-ulcer
● Hepatoprotective
● Slows intestinal motility
● No gonad toxicity
Vasodilation Effect
Note: Multiple studies confirm that piperine has multi-target and multi-pathway pharmacological activity.
Application direction
Used as an additive for brandy to give it a spicy taste. Also used as insecticide. In addition, it is the main anticonvulsant ingredient in Chinese prescriptions for treating epilepsy (white pepper and radish). It is used as a spicy raw material in the food industry and has a bactericidal effect.
