Factory Supply Lumbrokinase Powder 20000 IU
What Is Lumbrokinase？
Lumbrokinase, a proteolytic enzyme extracted from earthworms, exhibits excellent fibrinolytic activity and is effective in treating thrombosis and ischemic cardiovascular and cerebrovascular diseases. Currently developed nano-targeted drug delivery systems for lumbrokinase, or its combination with other drugs, can further enhance its bioavailability and safety. Lumbrokinase has been widely used in the treatment of thrombolysis and other diseases with significant efficacy.
Earthworms are one of the ingredients in the traditional Chinese medicine "Four Insects" formula. They have the effects of calming the liver and relieving wind, promoting diuresis, unblocking meridians, relieving asthma, clearing heat and relieving spasms. They are primarily used in the treatment of conditions such as hypertension and acute cerebral infarction. They have anti-inflammatory, analgesic, sedative, and hypnotic properties, and can prevent diabetes and kidney disease. Lumbrokinase, a fibrinolytic enzyme isolated and purified from the cultivated earthworm Eisenia fetida, has a stable structure, is absorbed in the small intestine, and is highly specific for fibrin. It can promote fibrinolysis through various pathways and is commonly used as an antithrombotic drug.
What Are The Pharmacological Effects Of Lumbrokinase?
Thrombolysis
Urokinase, tissue plasmin, and streptokinase are commonly used as thrombolytic agents to dissolve blood clots. However, none of these agents specifically recognize fibrin and are associated with adverse reactions and side effects, such as severe bleeding and hemorrhagic disorders. Lumbrokinase, on the other hand, not only specifically dissolves fibrin as a substrate but also converts plasminogen into plasmin by dissolving fibrin clots, without causing excessive bleeding. Furthermore, lumbrokinase demonstrates significant efficacy in dissolving blood clots, reducing whole blood viscosity, and reducing platelet aggregation, without adverse effects on the nervous system, respiratory system, cardiovascular system, liver, or kidney function.
Cardiovascular Protection
In clinical practice, experts have found that lumbrokinase has a significant effect on ischemic diseases. For example, myocardial ischemia-induced arrhythmias and myocardial damage are significantly reduced, and cardiac function is significantly improved, following the use of lumbrokinase.
Prevention of Hypertension
Researchers have found that lumbrokinase can inhibit spontaneously hypertensive syndrome-induced apoptosis in a rat model of secondhand smoke-induced cardiac apoptosis. They have also identified molecules that disrupt mitochondrial membrane potential via a mitochondrial pathway, suggesting that lumbrokinase may prevent spontaneously hypertensive syndrome and heart disease in non-smokers exposed to secondhand smoke.
Diabetes
Lumbrokinase has shown promising efficacy in treating diabetic complications. Patients with insulin-dependent diabetes often experience accumulation of insulin amyloid at the site of repeated insulin injections. This accumulation can lead to swelling or lumps, potentially affecting glycemic control and reducing the absorption of newly injected insulin, potentially preventing insulin from reaching the bloodstream. Lumbrokinase has a strong ability to degrade amyloid. Oral administration of lumbrokinase can reduce subcutaneous insulin-induced amyloid accumulation in the body, potentially impacting the treatment of diabetes.
Test report of Lumbrokinase
What are the indications?
Angina pectoris due to coronary heart disease: Improves myocardial blood flow and relieves symptoms.
Cerebral infarction: Quickly clears blocked blood vessels in the brain and reduces damage.
Diabetes complications: Prevents vascular lesions and improves microcirculation.
Nephrotic syndrome: Lowers fibrinogen levels and reduces the burden on the kidneys.
Cor pulmonale: Improves pulmonary blood flow and reduces the burden on the heart.
Deep vein thrombosis of the lower extremities: Dissolves blood clots and restores vascular patency. Improves myocardial blood flow and relieves symptoms.
Alzheimer's disease: Effectively prevents and alleviates Alzheimer's disease.
