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Factory supply Genistein 98% Powder
What is genistein?
Sophora japonica, a traditional medicinal plant, is gaining increasing attention in modern pharmacological research. Among its most representative active compounds is genistein (5,7,4'-trihydroxyisoflavone), a uniquely structured isoflavone. Due to its molecular similarity to 17β-estradiol, it is classified as a phytoestrogen. This natural bioactive compound is widely found in leguminous plants such as sophora flower, soybeans, and kudzu root. It exhibits a wide range of biological effects — from basic antioxidant and antibacterial properties to more significant functions like anti-cancer and cardiovascular protection. In particular, its potential in preventing and treating postmenopausal osteoporosis has gained international recognition.
The National Osteoporosis Foundation (NOF) of the United States has explicitly affirmed the bone-protective value of genistein. Although it still requires more clinical data to be approved as a safe ingredient by the FDA, it has already become an important target in the development of plant-based treatments for osteoporosis. The discovery of this "natural estrogen" not only provides a modern scientific explanation for the medicinal value of sophora flower, but also opens new avenues for the development of plant-derived functional ingredients.
What are the benefits?
1.Antibacterial Activity
● Mechanism of Action: Genistein disrupts the integrity of bacterial cell walls and membranes, and inhibits the tricarboxylic acid (TCA) cycle and protein synthesis.
● Application Prospects: With both antibacterial and antioxidant properties, genistein holds great potential as a functional food additive in the health and nutrition market.
2.Estrogen-like Activity
● Bidirectional Modulation: Genistein (GEN), the most biologically active component among soy isoflavones, exhibits phytoestrogen characteristics and can mimic or antagonize the effects of estrogen.
● Cellular Studies: In estrogen receptor-positive (ER⁺) breast cancer cells (MCF-7), genistein binds to estrogen receptors (ER) and regulates the expression of estrogen-responsive genes.
● Application: Useful for rapid screening of environmental estrogens and for research into hormone-related diseases.
3.Antioxidant Activity
● Effectively scavenges free radicals and reduces oxidative stress-induced damage.
4.Inhibition of Protein Tyrosine Kinase (PTK)
● Also inhibits topoisomerase II, interfering with DNA replication processes.
5.Bone Health
● Prevention of Osteoporosis: Especially beneficial for postmenopausal women, genistein can partially replace estrogen to maintain bone density. It has been recommended by the National Osteoporosis Foundation (NOF) in the United States.
Application direction
Genistein, a naturally occurring compound with multiple biological activities, demonstrates broad application potential in both the pharmaceutical and food industries. In the field of healthcare, its remarkable anti-osteoporotic effects and estrogen-like regulatory functions have attracted significant attention, particularly for their protective benefits on bone health in postmenopausal women. At the same time, genistein's antibacterial and antioxidant properties make it a valuable functional additive in the food industry—extending shelf life while enhancing the health value of products. This multifunctionality positions genistein as an ideal active ingredient for cross-sector applications, opening up new possibilities for the development of health supplements and functional foods.
