Factory Supply Calcium β-hydroxy-β-methylbutyrate Raw Material

Bidirectional Regulation of Muscle Protein Metabolism

This is the core and most thoroughly researched effect of calcium β-hydroxy-β-methylbutyrate (CaHMB), which works through a dual mechanism: on the one hand, it upregulates the protein synthesis signaling pathway, promoting muscle protein synthesis; on the other hand, it downregulates the protein breakdown signaling pathway, inhibiting muscle protein breakdown. Supplementation with CaHMB during progressive resistance training can significantly reduce the levels of muscle damage markers, alleviate muscle damage and accelerate recovery, while simultaneously improving muscle strength. Studies have confirmed that calcium β-hydroxy-β-methylbutyrate has a dose-dependent effect; supplementation at 1.5 g/day and 3 g/day can significantly increase the total strength of untrained individuals after three weeks of resistance training. Furthermore, when combined with eight weeks of resistance training, it can improve isometric and isokinetic strength in untrained individuals, improving overall muscle function. In addition, calcium β-hydroxy-β-methylbutyrate can also reduce muscle protein breakdown markers, delay muscle aging, and help maintain muscle mass.

Correcting Negative Nitrogen Balance

Negative nitrogen balance is a state in which the body's protein breakdown exceeds synthesis, and nitrogen intake is less than excretion. It is often caused by malnutrition, insufficient food intake, chronic wasting diseases, and severe tissue trauma. Prolonged negative nitrogen balance can lead to weight loss, worsening of illness, and in severe cases, even death. Relevant scientific research shows that supplementing with calcium β-hydroxy-β-methylbutyrate can effectively correct negative nitrogen balance: a randomized controlled study of 72 critically injured patients found that calcium β-hydroxy-β-methylbutyrate supplementation promoted protein synthesis and helped patients restore nitrogen balance; another study of 79 bedridden elderly patients receiving tube feeding also showed that after continuous supplementation with calcium β-hydroxy-β-methylbutyrate for 2-4 weeks, the patients' blood urea nitrogen and 24-hour urinary urea nitrogen excretion significantly decreased. This result indicates that calcium β-hydroxy-β-methylbutyrate can effectively slow down the rate of protein breakdown.

Health Benefits for the Elderly

With age, the body's muscle tissue naturally declines. Between the ages of 30 and 70, muscle mass decreases by an average of 6% to 8% every ten years. Meanwhile, the anabolic response to protein intake weakens in older adults, and coupled with reduced food intake, protein deficiency is common, leading to negative nitrogen balance and muscle atrophy. Related studies have shown that calcium β-hydroxy-β-methylbutyrate supplementation has significant benefits for muscle health in older adults: a randomized controlled study of 27 older women showed that continuous supplementation with calcium β-hydroxy-β-methylbutyrate for 12 weeks significantly reduced urinary nitrogen excretion, increased protein synthesis exceeding protein breakdown, thereby promoting lean body mass and muscle strength. Multiple clinical trials have also confirmed that calcium β-hydroxy-β-methylbutyrate can help older adults maintain muscle mass, increase muscle strength, and increase lean body mass. Notably, regardless of whether older adults engage in regular exercise, calcium β-hydroxy-β-methylbutyrate can produce positive clinical effects on skeletal muscle mass, strength, and function in adults aged 60 and older, effectively improving muscle condition even if high-intensity exercise is not possible due to physical limitations.

Enhancing Aerobic Metabolism

The precursor to calcium β-hydroxy-β-methylbutyrate (HMB) can enhance the body's aerobic metabolic capacity by upregulating the expression of the master regulator of mitochondrial biosynthesis, PGC-1α, activating AMPK kinase and Sirt1. This process promotes mitochondrial formation in muscle and fat cells, improves the efficiency of carbohydrate and fat metabolism, increases oxygen consumption, and reduces body fat accumulation; simultaneously, it can alleviate muscle damage, accelerate recovery, and indirectly help improve the body's aerobic performance.

Promoting Collagen Synthesis for Anti-Aging Repair

The youthful appearance of skin largely depends on the "reinforcing mesh" structure of collagen and elastin in the dermis. However, aging and external environmental stimuli accelerate the breakdown of this network—the rate of collagen fiber degradation exceeds the rate of synthesis, leading to signs of aging such as sagging and wrinkles.

Calcium β-hydroxy-β-methylbutyrate directly promotes the synthesis of dermal matrix proteins; simultaneously, it inhibits the activity of matrix metalloproteinases, reducing collagen fiber degradation, achieving a dual anti-aging effect of "promoting synthesis + inhibiting degradation."

Furthermore, calcium β-hydroxy-β-methylbutyrate can enhance the energy metabolism level of fibroblasts and promote ATP production, providing a sufficient energy basis for the continuous synthesis of collagen, thereby improving skin aging caused by decreased cell vitality.

Repairing the Skin Barrier

The skin barrier repairing effect of calcium β-hydroxy-β-methylbutyrate is mainly reflected in two aspects: First, it promotes the proliferation and differentiation of keratinocytes, accelerates the renewal of damaged stratum corneum, and helps restore the normal thickness of the stratum corneum; second, it regulates the synthesis of intercellular lipids, increases the content of key lipid components such as ceramides and cholesterol, thereby strengthening the water-locking capacity and structural stability of the stratum corneum.

Bidirectional Regulation of Muscle Protein Metabolism

This is the core and most thoroughly researched effect of calcium β-hydroxy-β-methylbutyrate (CaHMB), which works through a dual mechanism: on the one hand, it upregulates the protein synthesis signaling pathway, promoting muscle protein synthesis; on the other hand, it downregulates the protein breakdown signaling pathway, inhibiting muscle protein breakdown. Supplementation with CaHMB during progressive resistance training can significantly reduce the levels of muscle damage markers, alleviate muscle damage and accelerate recovery, while simultaneously improving muscle strength. Studies have confirmed that calcium β-hydroxy-β-methylbutyrate has a dose-dependent effect; supplementation at 1.5 g/day and 3 g/day can significantly increase the total strength of untrained individuals after three weeks of resistance training. Furthermore, when combined with eight weeks of resistance training, it can improve isometric and isokinetic strength in untrained individuals, improving overall muscle function. In addition, calcium β-hydroxy-β-methylbutyrate can also reduce muscle protein breakdown markers, delay muscle aging, and help maintain muscle mass.

Correcting Negative Nitrogen Balance

Negative nitrogen balance is a state in which the body's protein breakdown exceeds synthesis, and nitrogen intake is less than excretion. It is often caused by malnutrition, insufficient food intake, chronic wasting diseases, and severe tissue trauma. Prolonged negative nitrogen balance can lead to weight loss, worsening of illness, and in severe cases, even death. Relevant scientific research shows that supplementing with calcium β-hydroxy-β-methylbutyrate can effectively correct negative nitrogen balance: a randomized controlled study of 72 critically injured patients found that calcium β-hydroxy-β-methylbutyrate supplementation promoted protein synthesis and helped patients restore nitrogen balance; another study of 79 bedridden elderly patients receiving tube feeding also showed that after continuous supplementation with calcium β-hydroxy-β-methylbutyrate for 2-4 weeks, the patients' blood urea nitrogen and 24-hour urinary urea nitrogen excretion significantly decreased. This result indicates that calcium β-hydroxy-β-methylbutyrate can effectively slow down the rate of protein breakdown.

Health Benefits for the Elderly

With age, the body's muscle tissue naturally declines. Between the ages of 30 and 70, muscle mass decreases by an average of 6% to 8% every ten years. Meanwhile, the anabolic response to protein intake weakens in older adults, and coupled with reduced food intake, protein deficiency is common, leading to negative nitrogen balance and muscle atrophy. Related studies have shown that calcium β-hydroxy-β-methylbutyrate supplementation has significant benefits for muscle health in older adults: a randomized controlled study of 27 older women showed that continuous supplementation with calcium β-hydroxy-β-methylbutyrate for 12 weeks significantly reduced urinary nitrogen excretion, increased protein synthesis exceeding protein breakdown, thereby promoting lean body mass and muscle strength. Multiple clinical trials have also confirmed that calcium β-hydroxy-β-methylbutyrate can help older adults maintain muscle mass, increase muscle strength, and increase lean body mass. Notably, regardless of whether older adults engage in regular exercise, calcium β-hydroxy-β-methylbutyrate can produce positive clinical effects on skeletal muscle mass, strength, and function in adults aged 60 and older, effectively improving muscle condition even if high-intensity exercise is not possible due to physical limitations.

Enhancing Aerobic Metabolism

The precursor to calcium β-hydroxy-β-methylbutyrate (HMB) can enhance the body's aerobic metabolic capacity by upregulating the expression of the master regulator of mitochondrial biosynthesis, PGC-1α, activating AMPK kinase and Sirt1. This process promotes mitochondrial formation in muscle and fat cells, improves the efficiency of carbohydrate and fat metabolism, increases oxygen consumption, and reduces body fat accumulation; simultaneously, it can alleviate muscle damage, accelerate recovery, and indirectly help improve the body's aerobic performance.