Factory Supply 99% Lactulose Powder CAS 4618-18-2
What is Lactulose?
Lactulose is a synthetic disaccharide composed of D-galactose and D-fructose linked by a β-1,4-glycosidic bond. This substance does not exist in nature and appears as a pale yellow, transparent, viscous syrup or a white crystalline powder. It is readily soluble in water and exhibits high thermal and acid stability. The core characteristic of lactulose lies in its metabolic pathway: the human gastrointestinal tract lacks the enzymes capable of hydrolyzing this glycosidic bond, allowing it to pass intact through the upper digestive tract and reach the colon where it can be utilized by intestinal flora. Therefore, lactulose has wide applications in clinical medicine and health foods.
YTBIO supplies 99% lactulose using high-purity synthesis processes and strict quality control, committed to providing you with reliable health and metabolic management solutions.
COA OF lactulose
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ITEM |
STANDARD |
TEST RESULT |
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|
Assay |
>99.0% |
99.2% |
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|
Physical & Chemical |
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Appearance |
White to off-white crystalline powder |
Complies |
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|
Taste & Odor |
Characteristic |
Complies |
|
|
Particle Size |
100% pass 80mesh |
Complies |
|
|
Loss on Drying |
≤5.0% |
3.01% |
|
|
Water |
≤3 % |
1.2% |
|
|
PH |
4-6.5 |
5.2 |
|
|
Specific optical rotation |
-45°~ -49°(20°C, 589 nm)(c=5, whter) |
-46° |
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|
Sulphated Ash |
≤0.2 % (1.5 g) |
Complies |
|
|
Heavy Metal |
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Pb |
≤0.5ppm |
Complies |
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|
Lead |
≤0.5ppm |
Complies |
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|
B |
≤5.0ppm |
Complies |
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|
Microbiological Test |
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|
Total plate count |
≤1,000cfu/g |
410cfu/g |
|
|
Mold and Yeast |
≤100cfu/g |
45cfu/g |
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|
Coliform |
Negative |
Negative |
|
|
E.Coli |
Negative |
Negative |
|
|
Salmonella |
Negative |
Negative |
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Conclusion |
Conform with specification, Allergen Free, BSE/TSE Free. |
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Storage |
Store in cool and dry places. Keep away from strong light and heat |
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Packing |
By 25kgs/Drum, inner by double plastic bag |
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Shelf Life |
24 months under the above condition,and in it’s original package |
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Efficacy and Mechanism of Action
1. Altering Osmotic Pressure for Gentle Laxative Effects:
Lactulose has osmotic activity and is not absorbed in the small intestine after oral administration, entering the colon unchanged. Its molecules alter the osmotic pressure within the intestinal lumen through osmosis, retaining water and electrolytes in the lumen and increasing the water content and volume of colonic contents. This effectively expands the colonic wall, promotes intestinal peristalsis, softens stool, and achieves a gentle, non-irritating laxative effect.
2. Regulating Intestinal pH and Blocking Ammonia Absorption:
Once in the colon, lactulose is broken down and metabolized by beneficial bacteria such as lactobacilli and bifidobacteria, producing metabolites primarily composed of small-molecule organic acids (mainly lactic acid and acetic acid). This significantly lowers the intestinal pH. In this acidic environment, ammonia present in the intestine is converted into ammonium ions, effectively blocking ammonia from entering the bloodstream through the intestinal mucosa and reducing blood ammonia levels. Simultaneously, the acidic environment also reduces the absorption and accumulation of endotoxins and other substances.
3. Regulates Gut Microbiota：
Lactulose is a classic prebiotic that can be selectively utilized by beneficial microorganisms in the colon, promoting the proliferation and activity of probiotics. It not only improves the balance of the gut microbiota but also further optimizes the body's nitrogen metabolism by promoting bacterial synthesis of microbial proteins using ammonia.
4. Promotes Mineral Absorption
Studies have confirmed that the acidic environment created by lactulose fermentation in the colon helps improve the solubility and bioavailability of various minerals. Lactulose intake can significantly enhance the body's absorption efficiency of calcium (Ca) and magnesium (Mg) from food, a characteristic that makes it valuable in the fields of bone health and nutritional fortification.
Main Application Areas
1. Functional Foods and Health Supplements
Gut Health Management: Lactulose, as a high-quality prebiotic, is added to various health supplements for daily regulation of gut microbiota and improvement of digestive problems such as bloating and constipation.
Nutritional Supplements: Utilizing lactulose's mineral absorption-promoting properties, it can synergistically enhance bone health benefits when combined with calcium and magnesium supplements.
2. Clinical Uses
Treatment of Chronic Constipation: As an osmotic laxative, it is suitable for all population groups (including adults, children, and the elderly), improving bowel movement difficulties through physical regulation without the risk of dependence associated with stimulant laxatives.
Adjunctive treatment for hepatic encephalopathy: Used to prevent and treat elevated blood ammonia levels and related neurological symptoms caused by liver dysfunction. It helps improve nitrogen metabolism by acidifying the intestines and blocking ammonia absorption.
3. Infant Formula
Lactulose's prebiotic function and high safety make it widely added to infant formula to mimic the natural oligosaccharide function of breast milk, helping infants establish a healthy gut microbiota and reducing the incidence of constipation.
If you are interested in YTBIO's lactulose or other ingredients, please contact us through online consultation or other ways. We will provide you with technical support and customized solutions.
Email：sales@sxytbio.com
WhatsApp/phone：+86 17782577059
