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Wholesale Pure 98% Glycyrrhetnic acid Powder

Manufacturer Wholesale Pure Phlorizin Powder

Factory Supply 98% Phloretin Powder

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Factory Supply 98% Phloretin Powder

Specifications: 98%
Detection method: HPLC
Source: apple peel, root bark
CAS:60-82-2
Molecular formula: C15H14O5
Molecular weight: 274.27
EINECS:200-488-7
Shipping speed:1-3 days
Inventory:In stock
Certificates:cGMP,FSSC22000,BRC,HACCP, HALAL, KOSHER, ISO9001, ISO22000, FDA

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What is phloretin?

Phloretin, a naturally occurring flavonoid compound derived from apples, pears, and vegetable juices, is named after its primary presence in the root bark of fruit trees. Also known by its chemical name, trihydroxyphenol acetophenone, phloretin has been studied for over a century and plays a crucial role in protecting plants from UV radiation. With its distinctive pearl-white crystalline structure, phloretin is poorly soluble in water but dissolves well in ethanol and acetone, making it highly suitable for cosmetic applications.

In the skincare industry, phloretin demonstrates outstanding multifunctional properties. Its whitening effect is particularly remarkable, as it effectively inhibits tyrosinase activity, thereby blocking melanin production—outperforming traditional whitening agents like arbutin and kojic acid. Notably, when combined with other whitening ingredients, it exhibits a synergistic enhancement effect.

Beyond its whitening benefits, phloretin also regulates sebum secretion, aiding in acne treatment. Its exceptional moisturizing ability allows it to absorb a significant amount of water while enhancing the absorption of other active ingredients. Additionally, its strong antioxidant and anti-inflammatory properties make it a versatile and valuable addition to skincare formulations. These combined effects enable phloretin to be widely used in facial masks, serums, lotions, and other skincare products, providing comprehensive protection and care for the skin.

What are the benefits?

Antioxidant Effects

● Effectively neutralizes skin free radicals

● Inhibits lipid oxidation reactions

Whitening and Spot Removal Mechanism

● Specifically inhibits tyrosinase activity

● Blocks melanin production pathways

Transdermal Absorption Properties

● Lipophilic molecular structure

● Penetrates through intercellular lipid channels

Anti-Inflammatory Effects

● Inhibits the release of inflammatory factors

● Regulates chemokines and differentiation factors

Sun Protection Function

● Absorbs UV radiation

● Enhances the SPF/PA value of products

Antibacterial Properties

● Flavonoid-based antibacterial activity

● Broad-spectrum antibacterial effects

Moisturizing Mechanism

● Four hydroxyl groups form hydrogen bonds

● Provides significant water-locking and moisturizing effects

Hair Loss Prevention Applications

● Inhibits lipoxygenase activity

● Prevents premature aging-related hair loss

● Suitable for hair care products

Product Usage & Recommended Dosage

Specification	Recommended dose
Phloretin 98%	0.3%-2.0%

Phloretin is widely used in masks, lotions, essences, creams, sunscreens, shampoos, conditioners and other types of cosmetics and care products.

Research on phloretin and cosmetics

Pilot projects	Concentration	Effect description
Elimination of free radical DPPH	32umol/L	Elimination rate: 74.6%
Inhibition of lipid peroxidation	13umol/L	Inhibition rate: 53%
Promotion of type 4 collagen production by phloretin in cell culture	25ug/mL	Promotion rate: 201.6±20.6 (blank 100)
The protection of phloretin on apoptosis of stratum corneum cells under 1.0J/cm2 UVB irradiation	400ug/mL	Protection rate: 51.3%v9.6%
The promotion of brain amide production by phloretin in cell culture	2umol/L	Promotion rate: 164 (blank 100)
Inhibition of tyrosinase activity	0.05%	Inhibition rate: 82.2%
Inhibition of hyaluronidase activity	100ug/mL	Inhibition rate: 93.5%
Inhibition of 5α-reductase activity		Half inhibitory dose IC50: 84.3ug/mL
Inhibition of metalloprotease MMP-1 activity	5umol/L	Inhibition rate: 78%
Inhibition of interleukin IL-4 production		Half inhibitory dose IC50: >30umol/L
Inhibition of β-hexosaminidase activity	100ug/mL	Inhibition rate: 93.5%
Inhibition of transepidermal water evaporation by coating phloretin	50umol/L	Inhibition rate: 25% (compared with blank)