DNA Sodium/PDRN/Salmon PDRN
What is PDRN?
PDRN (polydeoxyribonucleotide) is a DNA fragment extracted and optimized from salmon sperm cells, and its INCI name is DNA sodium. This ingredient has a high similarity to human DNA (98% similarity) and excellent bioavailability, so it does not cause foreign body reactions. With its excellent skin repair and regeneration effects, PDRN has become an important ingredient widely used in the field of medical beauty.
PDRN - a technological breakthrough in skin regeneration and repair
1. Excellent skin regeneration ability
PDRN is a hydrolyzed regenerative tissue component that can quickly induce tissue regeneration, promote cell repair, and accelerate wound healing. It replenishes elastic fibers lost due to aging by activating the skin's own regeneration mechanism. After entering the human body, PDRN combines with cells, optimizes the internal environment of the skin, and effectively repairs skin damage caused by physical damage, chemical stimulation, and ultraviolet damage.
2. High biocompatibility
PDRN uses patented technology to extract and refine polynucleotides from salmon germ cells. Its DNA structure is 98% similar to that of humans, giving it a strong tissue repair ability. This high similarity prevents it from triggering immune rejection reactions in the human body, and it has excellent safety and compatibility. PDRN can deeply improve the physiological state of damaged skin and fundamentally solve a variety of skin problems.
3. Long-lasting anti-aging effect
PDRN activates adenosine A2A receptors on the cell surface, promotes the release of anti-inflammatory factors, repairs damaged cells, and stimulates the proliferation of fibroblasts, osteoblasts, and adipocytes. At the same time, it can promote the release of VEGF (vascular endothelial growth factor) and angiogenin, enhance blood circulation, make the skin fuller, firmer and more translucent, and thus achieve long-term anti-aging.
4. Strengthen the skin barrier
PDRN can promote VEGF secretion, accelerate angiogenesis, improve skin microcirculation, provide more oxygen and nutrients to cells, and thus accelerate tissue repair. It enhances the skin's moisturizing and resistance, helps rebuild a healthy barrier, improves skin thickness and elasticity, and is especially suitable for sensitive skin repair, reducing the impact of external stimuli.
5. Highly effective anti-inflammatory effect
Chronic inflammation is the root cause of many skin problems, which may cause redness, swelling and even pain. Studies have shown that PDRN can significantly inhibit inflammatory responses, regulate the expression of pro-inflammatory factors, and promote the production of anti-inflammatory factors, effectively alleviating skin redness, swelling and other problems. It has an improvement effect on inflammatory skin diseases such as neurogenic inflammation and rosacea, and can increase skin moisture and improve tolerance.
6. Inhibit melanin production
PDRN can reduce melanin synthesis, reduce tyrosinase activity, and inhibit the expression of related transcription factors, thereby improving pigmentation problems such as chloasma and photoaging spots, and helping the skin to restore uniformity and translucence.
PDRN has become a highly effective active ingredient in the field of modern medical beauty and skin care with its powerful regeneration and repair, anti-inflammatory and soothing, anti-aging and firming, and whitening and lightening effects. It is suitable for the comprehensive improvement of sensitive skin repair, barrier strengthening, anti-aging and inflammatory skin problems.
Test report
Applications
1. Application scope of PDRN with different molecular weights
700 KDa and above: suitable for skin regeneration, articular cartilage repair and bone formation promotion, mainly used in the field of medical regeneration.
350~500 KDa: used for drug treatment, such as tissue regeneration, corneal repair and treatment of musculoskeletal diseases.
40~60 KDa: used in cosmetics and functional foods, with main effects including skin barrier repair, anti-wrinkle and beauty improvement.
2. Core mechanism of action of PDRN
PDRN can be decomposed into nucleotides and nucleosides in the body, promote DNA synthesis, enhance fibroblast proliferation, and stimulate the expression of vascular endothelial growth factor (VEGF), thereby accelerating angiogenesis, improving microcirculation, and providing nutritional support for tissue repair.
At the same time, PDRN can inhibit the expression of inflammatory factors and apoptotic proteins, play a significant anti-inflammatory role, and protect cells from UV-induced DNA damage, comprehensively maintaining skin health.
Due to its adjustable molecular weight, PDRN is widely used in the fields of medicine, skin care and health food. It achieves efficient tissue repair and skin rejuvenation through multiple mechanisms such as promoting cell regeneration, enhancing repair ability, improving microcirculation and anti-inflammatory protection.
