Bulk N-Acetyl-D-Glucosamine NAG Powder CAS 7512-17-6
N-Acetyl-D-Glucosamine: Product Introduction
N-Acetyl-D-glucosamine (abbreviated as NAG) is a substance that occurs naturally within the human body and can also be obtained from external sources. Within the body, NAG is primarily derived from metabolic processes occurring in tissues such as bones, joint cartilage, skin, and hair cells; it plays an indispensable role in maintaining the structural integrity of joints, ensuring the balance of bone metabolism, and alleviating degenerative joint conditions. External N-acetyl-D-glucosamine mainly comes from food, such as seafood, oysters, sea urchins, and shrimp.
YTBIO supplies high-purity NAG raw materials. Our products are characterized by high biological activity, excellent water solubility, and ease of absorption; furthermore, our rigorous quality control measures ensure full compliance with relevant international standards for the food and dietary supplement industries. This raw material is widely utilized in the formulation of joint care supplements, functional foods, and skincare products. We are committed to providing our global clientele with a stable supply chain, customized services, and comprehensive, one-stop raw material solutions.
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Comparison of Core Parameters Between N-Acetyl-D-Glucosamine and Common Glucosamine |
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Comparison Dimension |
N-Acetyl-D-Glucosamine |
Common Glucosamine (Glucosamine Sulfate / Glucosamine Hydrochloride) |
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Metabolic Utilization Method |
Can be directly taken up by chondrocytes, and enter the cartilage matrix synthesis pathway without metabolic activation |
Requires multi-step acetylation conversion in the liver before it can be utilized by cartilage |
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Bioavailability |
Higher |
Relatively Lower |
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Transmembrane Absorption Rate |
3 times higher than that of glucosamine hydrochloride, which can quickly provide sufficient raw materials for cartilage repair |
Conventional Absorption Rate |
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Effective Dosage |
A low daily dose of 300-500mg can already show joint improvement effects |
A high daily dose of 1500mg is usually required |
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Joint Improvement Effect |
It is equivalent to or even better than high-dose common glucosamine in pain relief and joint function improvement |
A high dose is required to achieve a stable joint improvement effect |
Health Benefits
Joint Protection
Articular cartilage is an elastic connective tissue covering the ends of bones within a joint. Its core structure consists of proteoglycans, collagen, and hyaluronic acid, serving to cushion joint pressure and minimize friction between bones. N-acetyl-D-glucosamine (NAG) acts as the fundamental raw material essential for the synthesis of these substances. It plays an indispensable role in maintaining the structural integrity of joints, ensuring the balance of bone metabolism, and alleviating degenerative joint diseases.
Relevant studies indicate that, compared to standard glucosamine, N-acetyl-D-glucosamine is more effective in promoting the synthesis of glycosaminoglycans and sodium hyaluronate within knee joint chondrocytes, thereby protecting these cartilage cells. Sodium hyaluronate is a core component of both synovial fluid and the cartilage matrix; it helps maintain the elasticity and hydration of cartilage while enhancing the viscoelasticity and shock-absorbing capacity of synovial fluid.
Anti-inflammatory and Immunomodulatory Effects
Osteoarthritis is a condition characterized by cartilage degradation, synovial inflammation, and joint pain, triggered by the excessive release of inflammatory factors. N-acetyl-D-glucosamine promotes the synthesis of proteoglycans—key structural components of cell membranes and the extracellular matrix—which serve to stabilize cell membranes and strengthen intercellular connections, thereby demonstrating therapeutic efficacy in cases of subacute osteoarthritis. Furthermore, N-acetyl-D-glucosamine helps inhibit the immune-mediated degradation of proteoglycans and aids in the repair of damaged articular cartilage. By helping to reduce the release of inflammatory factors within the joint cavity, it alleviates symptoms such as joint swelling, stiffness, and pain, ultimately enhancing comfort during daily activities.
Improvement of Skin Condition
N-acetyl-D-glucosamine serves as a precursor to hyaluronic acid—the skin's natural moisturizer—and enhances the activity of hyaluronic acid synthase (HAS). Due to its low molecular weight and high permeability, it is effectively absorbed by the skin. It promotes the skin's endogenous synthesis of hyaluronic acid, thereby helping to diminish fine lines, improve skin elasticity and smoothness, and provide long-lasting hydration. Additionally, it inhibits the activity of tyrosinase—the enzyme responsible for melanin production—thereby offering effective skin-brightening and whitening benefits.
Application Areas Overview
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Country/Region |
Regulations |
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United States |
N-Acetylglucosamine (NAG) is included in the Dietary Supplements section of the United States Pharmacopeia. In the US, NAG has been widely studied and applied as a nutritional supplement ingredient to help maintain joint health. |
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Canada |
N-Acetylglucosamine is listed in the Natural Health Products Ingredients Database and can be used in natural health products. |
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Japan |
N-Acetylglucosamine is included in the Specifications and Standards List of Ingredients for Health Foods, and can be used in health foods.N-Acetylglucosamine can be used as a raw material for functionally labeled foods in Japan. |
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South Korea |
N-Acetylglucosamine is included in the Food Standards and Specifications by the Ministry of Food and Drug Safety, and can be used as a food ingredient.N-Acetylglucosamine is included in the Standards and Specifications for Health Functional Foods by the Ministry of Food and Drug Safety, and can be used as a raw material for health functional foods. |
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Taiwan, China |
N-Acetylglucosamine is included in the List of Ingredients Permitted for Use in Foods by the Food and Drug Administration of the Ministry of Health and Welfare, and can be used as a food ingredient. |
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China |
On August 5, 2024, the National Health Commission issued Announcement No. 3 of 2024, approving N-Acetylglucosamine produced by fermentation with Corynebacterium glutamicum RDG-2110 as a new food raw material. The recommended daily intake is ≤ 500 mg/d, and it can be applied in five dosage forms: milk and dairy products, beverages, jelly, candy, and pastries. |
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What can YTBIO offer you when sourcing N-Acetyl-D-Glucosamine powder?
Choose YTBIO for your N-Acetyl-D-Glucosamine procurement needs. We specialize in high-purity, fermentation-derived raw materials that are allergen-free and meet all quality specifications, backed by a complete set of qualification and testing documentation. We maintain ample stock in a wide variety of specifications, offer free samples, and provide comprehensive technical support for product formulation. With stable supply and excellent cost-performance, we are well-equipped to meet the diverse requirements of the food and cosmetics industries.
FAQ
Q: What production process do you use?
A: Adopts a biological fermentation process.
Q: In which fields can it be used?
A: Widely used in food, health supplements, skincare, and dietary supplements.
Q: What documents can you provide?
A: We can provide COA, MSDS, quality inspection reports, and full compliance documentation.
Q: How is the solubility?
A: Good water solubility, dissolves clear and free of impurities.
Q: Are samples available?
A: Free samples are available. Small trial orders are welcome; bulk orders can be placed after sample approval.
Q: What are the packaging & specifications?
A: 1kg and 25kg standard food-grade packaging, moisture-proof and sealed to prevent caking.
Q: Is the supply stable?
A: Regular stock on hand, sufficient production capacity, fast lead times, and long-term stable supply.
Q: Is quality guaranteed?
A: Strict batch testing is performed; heavy metals and microorganisms meet standards for reliable quality.
Q: Can you customize specifications?
A: Custom specifications and particle sizes are available to meet your formulation needs.
Why Choose YTBIO's N-Acetyl-D-Glucosamine?
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