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98% Chondroitin Sulfate Powder

Specifications: 98%

 

Detection method: HPLC

 

Shipping speed: 1-3 days

 

Inventory: In stock

 

Certificates: HACCP, HALAL, KOSHER, ISO9001, ISO22000, FDA

 

MOQ: 25KG

 

Package: 25Kg/barrel

 

Sales group: not for individual customers

    What is chondroitin sulfate?

    Chondroitin sulfate (CS) is a type of glycosaminoglycan that forms proteoglycans through covalent bonding with proteins. It is widely distributed in the extracellular matrix and on the cell surfaces of animal tissues. Its sugar chain is composed of alternating glucuronic acid and N-acetylgalactosamine, which are linked to the core protein through a glycosidic linkage to the serine residue. Although the backbone structure of chondroitin sulfate is relatively simple, it exhibits a high degree of heterogeneity in terms of sulfation levels, the distribution of sulfate groups, and the arrangement of uronic acid isomers. This intricate structure determines the functional specificity of chondroitin sulfate and its interactions with various protein molecules.

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    The production of chondroitin sulfate typically employs an extraction method utilizing cartilaginous tissue.

     

    The specific process is as follows:


    1. Material Selection: Select fresh, clean, and mature animal cartilage—such as that from chickens, geese, or cattle—to serve as the raw material.
    2. Cleaning: Wash the cartilage to remove surface impurities.
    3. Crushing: Crush the cleaned cartilage into uniform granules.
    4. Extraction: Place the cartilage granules into a vessel, add an appropriate amount of water, and bring the mixture to a boil.
    During the boiling process, the chondroitin sulfate contained within the cartilage dissolves into the water.
    5. Filtration: Filter the boiled cartilage solution to remove solid particles and impurities.
    6. Concentration: Concentrate the filtered solution through evaporation to increase the concentration of chondroitin sulfate within the liquid.
    7. Precipitation: Induce the precipitation of chondroitin sulfate from the solution by adding a precipitating agent, such as hydrochloric acid or sulfuric acid.
    8. Separation: Separate the precipitated chondroitin sulfate from the solution, typically utilizing separation equipment such as a centrifuge.
    9. Washing: Wash the precipitated chondroitin sulfate to remove residual substances, such as hydrochloric acid or sulfuric acid.
    10. Drying: Dry the washed chondroitin sulfate precipitate to achieve the desired moisture content.
    11. Pulverization: Pulverize the dried chondroitin sulfate into fine granules.
    12. Packaging: Package the pulverized chondroitin sulfate for storage and transportation.The production of chondroitin sulfate typically employs an extraction method utilizing cartilaginous tissue. 

    Structure

    Chondroitin sulfate is a linear, water-soluble glycosaminoglycan, with its basic building blocks being N-acetylgalactosamine and glucuronic acid. These two monosaccharides are repeatedly cross-linked to form a linear molecular chain via β-1,4-glycosidic bonds (between N-acetylgalactosamine and glucuronic acid) and β-1,3-glycosidic bonds (between glucuronic acid and N-acetylgalactosamine).
    Chondroitin sulfate is mainly divided into chondroitin sulfate A and chondroitin sulfate C. The difference between them lies in the position of the sulfate group: in chondroitin sulfate A, the sulfate group is attached to the 4th carbon of N-acetylgalactosamine, whereas in chondroitin sulfate C, the sulfate group is attached to the 6th carbon of N-acetylgalactosamine.

    What are the benefits?

    Clearing Oxygen Free Radicals

     

    Chondroitin sulfate has significant antioxidant properties and can effectively remove hydroxyradicals and superoxide anion radicals, which are the main reactive oxygen species thatcause oxidative damage in the body. Studies have shown that the half-maximal inhibitoryconcentrations of chondroitin sulfate for hydroxyl radicals and superoxide anion radicals are8.77 mg/mL and 0.94 mg/mL, respectively. Its scavenging ability is directly related to itsconcentration and purity, thereby protecting the body from oxidative damage and exertinganti-aging effects.

     

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    Prevention and Treatment of Arthritis

     

    Chondroitin sulfate is an important drug for treating joint diseases, often used in combinationwith glucosamine. It can alleviate joint pain, promote cartilage regeneration, andfundamentally improve joint issues. In the United states, chondroitin sulfate is used as adietary supplement to lubricate and support joints by binding to water molecules, improvingjoint mobility, and ensuring free joint movement.Prevention and Treatment of OsteoporosisResearch shows that chondroitin sulfate can significantly increase bone mineral content andbone density, reduce serum alkaline phosphatase levels, and improve the biomechanicalparameters of the femur, offering therapeutic effects for osteoporosis.

     

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    Eye Protection

     

    Chondroitin sulfate has a protective effect on corneal collagen fibers, promoting cornealwound healing, absorption of exudate, and inflammation reduction. It is often formulated withother drugs into compound eye drops for preventing eye fatigue, conjunctival congestion,itching, and treating dry eye syndrome.

     

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    Other Effects

     

    Chondroitin sulfate can also be used to treat neuralgic headaches, trigeminal neuralgia,coronary heart disease, angina pectoris, myocardial hypoxia, cardiovascular diseases, jointpain, atherosclerosis, and hepatitis. Additionally, it has anticoagulant and antithrombotic effects and can be used as an adjunctive treatment for hearing impairment and liver damage caused by streptomycin, as well as for hyperlipidemia.

     

     

    Uses

    The primary medical application of chondroitin sulfate is as a treatment for joint diseases, often used in combination with glucosamine. It has pain-relieving and cartilage-regenerating effects, which can fundamentally improve joint issues. Randomized placebo-controlled clinical trials have shown that chondroitin sulfate significantly reduces pain in osteoarthritis patients, improves joint function, reduces joint swelling and effusion, and prevents narrowing of the joint space in the knee and hand joints.
    Chondroitin sulfate works by providing cushioning, reducing impact and friction during movement. It absorbs water into the proteoglycan molecules, thickening the cartilage and increasing the amount of synovial fluid in the joint. Additionally, chondroitin sulfate acts as a delivery system, transporting oxygen and nutrients to the joint, helping to clear waste within the joint while expelling carbon dioxide and other waste products. Since joint cartilage lacks a direct blood supply, its oxygenation, nourishment, and lubrication rely entirely on synovial fluid, making chondroitin sulfate crucial in maintaining joint health.
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    FAQ

     

    Q: Do you support customization and large-volume supply?
    A: Definitely. We can customize formulas and product specs, and we are capable of bulk supply.
    Q: How fast is your shipping?
    A: Standard items are stocked locally and can be delivered promptly.
    Q: What supporting services do you offer?
    A: We deliver complete one-stop solutions from pre-sales advice and technical guidance to after-sales assistance.
    Q: Are samples available?
    A: Yes, we can provide samples. Please get in touch with us to arrange samples.

     

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