50000 iu/g Mannanase Powder Factory
Mannanase: Product Introduction
Mannanase, also known as β-mannanase, is a highly efficient endonuclease. It precisely targets the polysaccharide backbone containing β-1,4-mannoglycosidic bonds (such as mannan, galactomannan, and glucomannan), randomly cleaving it into oligomannoses and monosaccharides. This enzyme is widely found in microorganisms, plants, and animals. Its core value lies in eliminating the anti-nutritional effects of mannan, as high-molecular-weight mannan increases intestinal chyme viscosity and encapsulates nutrients such as starch and protein, hindering digestion and absorption. Mannanase is widely used in the feed industry, health foods, and other industrial fields.
YTBIO's mannanase boasts an enzyme activity of 50,000 IU/g and exhibits excellent thermal stability and acid-base tolerance, making it an ideal raw material for improving bioavailability and overall health.
Efficacy and Mechanism of Action
1. Eliminating Anti-Nutritional and Immune Stress
High molecular weight β-mannan increases intestinal chyme viscosity, encapsulating nutrients such as starch and protein, and hindering endogenous enzymes from contacting substrates. Furthermore, its structure can be recognized by intestinal immune cells as a pathogen-associated molecular pattern (PAMP), activating the TLR4/NF-κB inflammatory pathway, inducing the release of pro-inflammatory factors such as TNF-α and IL-6, and triggering chronic low-level immune activation, leading to unnecessary energy consumption for growth. β-mannanase efficiently degrades β-mannan through endo-hydrolysis, eliminating these negative effects at the source.
Research data shows that adding mannanase can significantly reduce intestinal chyme viscosity, while simultaneously decreasing serum TNF-α levels by 28% and downregulating intestinal TLR4 receptor expression, effectively relieving immunosuppression and redirecting nutrient flow to growth and production.
2. Strengthening the Intestinal Barrier
Mannanase can alleviate inflammatory stimulation and help maintain the tight junction structure between intestinal epithelial cells. Experiments have confirmed that the addition of mannanase significantly increases the expression levels of key tight junction proteins Occludin and ZO-1 in the jejunum of piglets by 29%-35%, reduces intestinal permeability, and effectively prevents the migration of endotoxins (LPS) and pathogens across the intestinal wall. Simultaneously, the degradation products synergistically stimulate intestinal goblet cells to secrete mucin, thickening the chemical barrier and increasing the concentration of secretory immunoglobulin A (sIgA), thus strengthening local mucosal immune defense.
3. Regulation of Microbiota and Immunity
The enzymatic hydrolysis product of this product, mannooligosaccharide (MOS), has significant prebiotic properties.
Promoting the proliferation of beneficial bacteria: MOS can serve as a fermentation substrate for beneficial bacteria such as Lactobacillus and Bifidobacterium. After using this product, the relative abundance of Lactobacillus in the hindgut of animals increased by more than 2.1 times, while the number of endotoxin-producing Enterobacteriaceae bacteria significantly decreased.
Inhibiting pathogens: The proliferation of beneficial bacteria reduces the pathogen load through competitive exclusion and the inhibitory effect of metabolites, thereby alleviating the systemic inflammatory burden.
Immunomodulation: Proliferating gut microbiota ferments short-chain fatty acids (SCFAs), among which butyrate can induce regulatory T cell (Treg) differentiation, establishing intestinal immune tolerance and maintaining healthy immune homeostasis.
Application Areas
β-Mannanase has broad application prospects in multiple industries:
Feed Industry (Core Application)
Mannanase, applied to corn-soybean meal diets, effectively degrades anti-nutritional factors in soybean meal and palm kernel meal, releasing encapsulated energy and protein, significantly reducing the feed conversion ratio, and improving broiler weight gain and laying hen egg production performance.
Simultaneously, in the trend of replacing antibiotics, mannanase, through its immunomodulatory properties and the production of active prebiotics (MOS), regulates gut microbiota, inhibits pathogen colonization, and enhances the overall health of animals.
Food Industry
Functional Food Additives: Mannanase is used to enzymatically hydrolyze konjac gum, guar gum, etc., to produce oligomannans (MOS), which are added as high-quality prebiotics to dairy products and beverages, possessing the functions of regulating gut microbiota and enhancing immunity.
Food Processing: Mannanase can also be used in juice clarification, coffee bean degumming, and beer brewing, helping to improve product clarity, taste, and juice yield.
Other Applications:
In pulp bleaching, it degrades hemicellulose, improving bleaching agent penetration efficiency and reducing the amount of chemical agents used.
If you are interested in YTBIO's mannanase or other raw materials, please feel free to contact us via online consultation or email. We will provide you with professional technical support and customized solutions.
Email：sales@sxytbio.com
WhatsApp/phone：+86 17782577059
